Dating of multidose vials

For many years, AAS have been by far the most detected doping substances in IOC-accredited laboratories.Beyond use dates are different from expiration dates.

Acceptance of such different tablet appearances in the specification of a single strengthproduct would formally also allow the company to dispense these two appearances in the same container/blister, which may even cause greater confusion.

In addition, it is not clear to which extent such different appearances would have an effect on patient / user acceptability.

Moreover, the introduction to the variation classification guidelines (2013/C 223/01) includes the following statement: "References in this Annex to changes to the marketing authorisation dossier mean addition, replacement or deletion, unless specifically indicated." For the purpose of illustration and comparison, change code B.

Variolae vaccinae...known...[as]..Cow Pox, in which he described the protective effect of cowpox against smallpox.

Sometimes, protection fails because the host's immune system simply does not respond adequately or at all.